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TDP-43 Q331K transgenic mice have a lower CMAP than their wild type litter mates at 3 and 6 months of age 25
This discomfort is usually mild and related to changes in gut bacteria or irritation of the stomach
A second factor has been pleiotropy, which was historically interpreted as a liability rather than a potential advantage
Could improve skeletal muscle energy metabolism , possibly increasing how many calories the body can burn
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