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Altered B12 handling and reduced clearance in kidney disease, and both cellular release and reduced clearance in liver disease, can raise B12, so supportive renal or hepatic findings make those causes plausible

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Subgroup analysis in patients with positive baseline C-peptide levels showed a more robust reduction of HbA1c (i.e., 0.69-0.83%) on GLP-1RA in this group (62)

Semaglutide brand names are Ozempic, Rybelsus, and Wegovy, all made by Novo Nordisk