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However, due to aging, stress, diseases, or environmental factors, these antioxidants can decrease over time

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Modulated expression of 4,000+ human genes in cultured fibroblasts Upregulated antioxidant genes including SOD and glutathione peroxidase Downregulated pro-inflammatory and tissue-destructive gene networks Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data2014Gene Expression Analysis using the Broad Institute Connectivity Map reveals GHK-Cus gene expression signature overlaps with tissue-remodeling, anti-cancer, and neuroprotective pathways, extending its potential research applications

This remodeling capacity is key to its wound-healing effects GHK-Cu promotes organized tissue repair rather than scar formation

"Identification of PAD2 as a gamma-glutamylcysteine synthetase highlights the importance of glutathione in disease resistance of Arabidopsis" (PDF)