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Nat Rev Clin Oncol 23 , 459470 (2026)
In the published literature, afamelanotide is studied as an agonist at melanocortin receptors, principally the melanocortin-1 receptor (MC1R), within in-vitro systems and pre-clinical models
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In some cases, mast cells can produce identical clones that are spontaneously released, stimulating these mediators and triggering an allergic reaction
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