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N Engl J Med Sept 2 2024, doiEpub ahead of print, PMID

leptin (red, 2 mg/kg body weight) or vehicle (black) injection on cumulative ad libitum food intake in 12- to 18-week-old male WT ( C ) and Bbs5 / ( D ) mice over 24 hours ( n = 9 per group)

At 24 weeks, liver fat reductions were significant: 42.9% (1 mg), 57.0% (4 mg), 81.4% (8 mg), and 82.4% (12 mg), compared to a 0.3% increase in the placebo group

Standard (5 mg/mL) provides a balanced approach for most research scenarios

Fatigue rates are similar, around 10% to 15%

These variables can introduce biases in the results, and we have discussed their potential impact in the results and discussion section