Probiotic supplementation may improve body weight, BMI, fasting glucose, insulin resistance (HOMA-IR), lipid profiles (triglycerides and very low-density lipoprotein (VLDL)-cholesterol), inflammatory markers such as C-reactive protein (CRP), and oxidative stress indicators including malondialdehyde (MDA), total antioxidant capacity (TAC), and glutathione (GSH), and hormonal parameters (total testosterone, SHBG), while also alleviating hirsutism in PCOS patients (105, 106)
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These changes can create temporary disruption before improvement emerges
10.1016/j.cell.2017.09.044 Cell 117 WuT
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However, these findings are based on preclinical studies, and the effectiveness of BPC 157 in humans is still under investigation