ER stress-related transcription factors ATF4 and ATF6 suppress LAMP2, essential for autophagosome-lysosome fusion, leading to impaired autophagic flux and cellular waste buildup
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In men, prolonged stress can lower testosterone and DHEA, impacting skin and immune health
Primary research areas include gastrointestinal tract studies (gastric ulcer, inflammatory bowel models, esophagitis, fistula healing), musculoskeletal tissue studies (Achilles tendon transection, ligament healing, muscle crush injury), and neuroprotective models (dopaminergic system interactions, peripheral nerve transection)
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