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Some people cope with stress using substances such as alcohol or cannabis

Pico lasers : Ultra-short pulse lasers that target pigment with reduced thermal effect on surrounding tissue

Neurobiol Aging 35(9):20792090

Data from Phase 2 trials (Jastreboff et al., NEJM 2023) provide the most detailed safety information currently available, though it is important to recognise that longer-term safety data from Phase 3 trials are still being gathered

They are often taken together for potential benefits in cardiovascular health, metabolic control, and neuroprotection, though robust evidence for synergistic effects remains limited