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Slightly higher doses of CCK-8 administered via intraperitoneal injection (~110 g/kg) activate vagal afferents and increase neuronal activation in the NTS where VANs terminate, while vagotomy and capsaicin treatment abolish the suppressive effects of CCK-8 administration 177,178

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Most commonly, patients experience digestive symptoms such as nausea, vomiting, diarrhea, constipation, or abdominal discomfortespecially in the first few weeks of treatment or after increasing your dose