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Double-blinded trial providing evidence that once-weekly semaglutide could achieve weight loss in participants with obesity, which can lead to insulin resistance and type 2 DM

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Interestingly, we found that improved glucose metabolism in hypothyroid mice after T3 treatment was accompanied with increased GLP-1 production and insulin secretion

Neurochem Res 15:597601 Whitmer JT, Idell-Wenger JA, Rovetto MJ, Neely JR (1978) Control of fatty acid metabolism in ischemic and hypoxic hearts

No effects on cell cycle was observed

Relative gene expression was calculated after normalization to a house-keeping gene (mouse or human 18S rRNA)