Therefore, in line with 3 R animal experimental principles, we chose to conduct our proof-of-concept study directly in elephants since an in-target-species trial in a real-world setting provides an accurate reflection of the vaccines safety and immunogenicity, avoiding reliance on models that poorly recapitulate elephant immunology
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Neurons, specifically, rely primarily on glucose, although they can also use alternative fuels in specific situations (e.g., ketone bodies under prolonged fasting or keto diets [31])
Next was semaglutide, marketed as Wegovy for weight management, and as Ozempic and Rybelsus for diabetes, and then tirzepatide, marketed as Zepbound for weight management, and as Mounjaro for diabetes