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Assessed by positron emission tomography-computed tomography (PET-CT) in our clinical practice, we found that the brain glucose uptake of patients who underwent RYGB was improved after surgery, and to dissect the possible mechanism of bariatric surgery in improving brain glucose uptake, thus favoring a better cognitive function, DJB and sham surgery were performed on obese and diabetic Wistar rats and intracerebroventricular (ICV) injection of GLP-1 analog liraglutide (Lira) and antagonist exendin-(939) (Exe-9), along with the viral-mediated GLP-1 receptor ( Glp-1r ) knockdown (KD) were applied to elucidate the role of GLP-1 in mediating cognitive function and brain glucose uptake using the Morris water maze (MWM) test and PET

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