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48% discontinuation among weight loss GLP-1 users 33% discontinuation among diabetes GLP-1 users Discontinuation of GLP-1 therapy is associated with metabolic rebound, including weight regain, rising blood pressure, and worsening glycemic control, undermining both clinical outcomes and the value of initial investment

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Furthermore, islet GLP-1 staining was higher in liraglutide-treated WT mice compared with that in liraglutide-treated KO mice (Figure 1, B and C

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