Elastin fibers are damaged and have limited capacity to regenerate naturally (adult humans produce very little new elastin after puberty under normal conditions)
Using sterile water without preservative would require discarding unused portions after each use, which is wasteful and impractical
D.TrojanowskiJ
It is recommended that the maximum duration is 2 months then taking the same duration off, so 2 months on, 2 months off
CHCHD2 is also important in maintaining the cristae structure and preventing apoptosis
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