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Vitamin B12 deficiency can cause fatigue, memory and cognitive loss, myalgias(leg and back pain), poor digestion, mood changes, hair loss, weight gain due to poor metabolism

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For some patients, regenerative strategies may serve as a complement to conventional care

Ice-crystal formation during each freeze-thaw cycle inflicts mechanical damage on peptide chains, and pre-splitting eliminates the cumulative loss that comes from thawing one vial multiple times

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These effects were generally mild and transient