For GHK-Cu, the most defensible dosage discussion comes from published topical study designs and clinical-trial protocols, not from unsourced injectable peptide therapy schedules [2], [3], [7], [8]
I pulled one of those levers, or a few of them, and it wasn't linear
One study demonstrated that exendin-4 (50 nM) treatment reduces the expression of pro-inflammatory genes such as NF-B p65 and the TNF receptor superfamily member 1A in human pancreatic islet cells (Velmurugan et al., 2012)
Common reasons Dose too low - may need to increase to therapeutic levels (2.4mg or higher) Not enough time - meaningful results typically take 8-12 weeks at adequate doses Calorie-dense liquid calories bypassing satiety signals - watch smoothies, alcohol, sugary drinks Eating through fullness signals - pay attention to your body's cues Inconsistent dosing schedule - must be same day each week for optimal levels Unrealistic expectations - 1-2 lbs per week is healthy, sustainable weight loss Key Research [1]"Once-weekly cagrilintide for weight management in people with overweight and obesity" Lau DCW et al., 2021 Finding: Phase 2 trial showed cagrilintide at 4.5mg achieved 10.8% weight loss versus 3% with placebo over 26 weeks in 706 participants
Payne, C., Wiffen, P
Some plans cover brand-name medications (Wegovy, Zepbound) prescribed via telehealth, though prior authorization is typically required