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however, in inflammatory disease states, particularly when intestinal barrier integrity and function may be compromised, LPS can enter the circulation, where it can activate TLR4 on inflammatory cells and trigger a systemic inflammatory response

Dunn L, Flenady V, Kumar S

We show that the heterogeneity in mitochondrial function and signalling observed across CRC samples could explain, and be used to predict, poor clinical responses in patients with locally advanced CRC

Elevated OS has been associated with systemic manifestations, including heightened lipid peroxidation, which correlates with mood disturbances, sleep disorders, and other health concerns (152)

SLC7A11 is primarily responsible for regulating Xc system activity 9