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J Biol Chem 1992;267:9300-6

Biochemically, C4A exhibits higher affinity for amino groups, whereas C4B binds more readily to hydroxyl groups, suggesting that C4A may be more involved in binding immune complexes and protein antigens, while C4B plays a more important role in binding carbohydrate-rich microbial antigens (145)

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The study results showed a statistically significant increase of acne pustules, papules, and comedones in these men after the 30 days

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