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Materials and Methods Experimental Animals and Groups In our study, we raised 120 specific pathogen-free (SPF) grade Wistar male rats (180 20 g weight and 24 weeks old, which is equivalent to 1820 years old in humans) provided by the Experimental Animal Center of the 940th Hospital of Joint Logistics Support force of Chinese Peoples Liberation Army (licence: SCXY (Military) 20120020)

Combined with potential GI side effects, this may lead to fluid and electrolyte loss, making intentional hydration more important

Interestingly, the tri-agonist also preserved the islet architecture by significantly reducing alpha-cell infiltration into the core of pancreatic islets

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[13] In combination with a reduced-calorie diet and increased physical activity, semaglutide (as Wegovy) is indicated to reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke) in adults with established cardiovascular disease and who are either obese or overweight

While modest, this improvement was sustained at both 26-week and 52-week assessments