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This pharmacovigilance system is crucial for identifying previously unrecognised adverse effects, monitoring the safety profile of newly licensed medications like Mounjaro, and detecting rare but serious reactions that may not have been apparent during clinical trials

When these compounds were tested in INS-1 832/3 beta cells 21 with a prolonged incubation to mimic in vivo drug exposure, we found that compounds exhibiting higher internalization also had reduced maximal insulin release (Fig

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This combination makes GLP-1 treatments an effective solution for long-term weight management