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Call 911 or seek immediate medical attention if you experience: Black, tarry stools or blood in vomit (coffee-ground appearance), which may indicate gastrointestinal bleeding Severe or persistent abdominal pain that differs from typical semaglutide-related discomfort Sudden onset of chest pain, shortness of breath, or symptoms of heart attack or stroke Signs of allergic reaction, including rash, swelling, or difficulty breathing Decreased urine output, swelling in the legs or feet, or other signs of kidney problems Semaglutide can rarely cause pancreatitis