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It is one of the important cofactors that helps transport long-chain fatty acids into the mitochondria for proper mitochondrial function

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Applying an ice pack or cold compress may also bring relief

In mammals, it is already well-known that key detoxification enzymes, like GSTs, show strong circadian transcriptional regulation (Abhilash et al., NtGST in tobacco plants

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2010 Dec;92(6):1369-77