A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007
Experts do not recommend B12 shots for weight loss
Importantly, 5MQ was found to effectively inhibit HeLa cell proliferation without apparently affecting normal HEK-293 cell proliferation suggesting selectivity for cancer cell biology contexts
Call your health care provider immediately if you are experiencing any signs of an allergic reaction: skin rash, itching or hives, swelling of the face, lips, or tongue, blue tint to skin, chest tightness, pain, difficulty breathing, wheezing, dizziness, red, swollen painful area on the leg
Some people experience digestive upset from high-dose B12 supplements
Human data semaglutide/tirzepatide: extensive, approved for type 2 diabetes and obesity