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Acknowledgements We would like to acknowledge the following funding sources: R01 CA196660, P50 CA121974, P01CA128814, the Melanoma Research Alliance, the Melanoma Research Foundation and the Hervey Family Foundation (to MB)
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Many studies have shown a link between the risk of cardiovascular diseases and the production of TMA by intestinal bacteria, which is further converted to trimethylamine N-oxide (TMAO) by hepatic enzymes (Tang et al
Both medication classes influence metabolic processes, though through different mechanisms, making it important to consider potential interactions and cumulative effects on the body's hormonal and metabolic systems
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A significant slowing of biological processes linked to age-related disease and all-cause mortality risk, as measured by the PCGrimAge epigenetic clock
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