Rare allergic reactions, including anaphylaxis, have been reported
For patients without absorption disorders, high-dose oral B12 supplements (1,000-2,000 mcg daily) have been shown to be comparably effective to injections in correcting mild to moderate deficiency
Susceptibility to thyroid autoimmune disease: molecular analysis of HLA-D region genes identifies new markers for goitrous Hashimotos thyroiditis
Taquet M, Geddes JR, Husain M, Luciano S, Harrison PJ
Genetic and transcriptomic biomarkers Using high-throughput sequencing technologies, researchers can identify ferroptosis-related molecular markers at the genetic and transcriptomic levels
So most of the evidence comes from animal models , experiments on animals, most often rats