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Hellweg, R., Raivich, G., Hartung, H
A rigorous 2022 systematic review and meta-analysis of randomized controlled trials found that L-carnitine supplementation significantly reduces blood lactate accumulation during physical exertion
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Oxytocin stimulation of the oxytocin interneurons resulted in production of GABA and cortisol release hormone binding protein (CRHBP), which inhibited the stress/anxiety behavior mediated by cortisol releasing hormone within layer 2/3 pyramidal neurons associated with cortisol releasing hormone release
V., Sablina A
After 12 weeks, the researchers noted that the group receiving L-carnitine did indeed show improvements in fatigue, with the most significant improvements seen in brain fatigue. The most significant results were in those younger than 50, those over the age of 50 with high levels of free T3, and those who had hypothyroidism due to a thyroidectomy (who were taking relatively high doses of thyroid hormone)
