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Acknowledgements This material is the result of work supported with resources and the use of facilities at the Orlando VA Healthcare System (Orlando, Florida)

Poor blood sugar control and obesity are closely linked in a cycle where each can contribute to the other: high blood sugar caused by insulin resistance results in excess production of insulin, which in turn encourages the body to store fat, while obesity worsens insulin resistance

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Pyrimidine Ring Formation: The cyclization temperature must be controlled within 2C to prevent the formation of dimerization impurities

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Starting and stopping a medication can be detrimental and will all but guarantee weight regain and future difficulty losing weight. Monitoring body composition during treatment can provide critical information