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These findings indicate that GpoA, TpxD, and AhpD constitute a robust H 2 O 2 detoxification system that depends on extracellular GSH uptake

[164] In March 2023, a Novo Nordisk official said, based on a randomized, double-blind study (NCT03548935 [165] ) funded by the company, that people using semaglutide to lose weight regained two-thirds of their original weight loss one year (52 weeks) after discontinuing use of the drug

Basal ROS levels ( d ), lipid ROS levels ( e ), and relative MDA levels ( f ) were measured

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These are unstable molecules that can cause damage to cellular structures, including DNA and proteins