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Key Takeaways Tirzepatide was associated with lower 12-month risks of new or worsening diabetic retinopathy compared with lifestyle intervention alone Tirzepatide users had fewer vision-threatening complications and were less likely to require intravitreal anti-VEGF injections or panretinal photocoagulation The retrospective study included 173,846 propensity-matched patients with diabetes and overweight or obesity across 70 US health systems Patients with diabetes who initiated tirzepatide had lower rates of diabetic retinopathy, vision-threatening complications, and retinal interventions than matched patients receiving lifestyle intervention alone, according to a large retrospective study published in Ophthalmology

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