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Renal excretion is the primary clearance pathway

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The side-chain guanidyl group of Arg454 interacts with the carboxylate moiety of glycine to orient the substrate for attack on the acyl-phosphate intermediate (Herrera et al., 2007)

This enhances the cells intrinsic capacity to counteract oxidative damage while preserving GSH, a crucial non-enzymatic antioxidant 165

Whitby PW, VanWagoner TM, Springer JM, Morton DJ, Seale TW, Stull TL