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Graphical Abstract Similar content being viewed by others Introduction Diabetic kidney disease (DKD) is one of the most prevalent and severe microvascular complications of diabetes, affecting approximately 3040% of diabetic patients worldwide and remaining the leading cause of end-stage renal disease (ESRD) [1, 2]

The large increase in metabolic demand during the first postnatal month may partly reflect that instead of purely neuronal uptake of glutamate and GABA during very early postnatal development, virtually all glutamate and some GABA now becomes accumulated twice

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Drinking more water helps reduce urine smell