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Given this interplay, weight loss is a cornerstone of managing patients with coexisting obesity and KOA

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Metabolic Research Lipolysis and Fat Metabolism Animal studies have investigated the metabolic effects of enhanced growth hormone secretion: Growth hormone-mediated lipolysis through hormone-sensitive lipase activation Increased free fatty acid availability for energy utilization Preferential reduction of visceral adipose tissue in preclinical models Improved insulin sensitivity markers in some experimental conditions Research suggests growth hormone elevations enhance lipid oxidation while preserving lean tissue during energy restriction

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The agency issued 11 WLs in FY25 following the review of promotional materials