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Regarding altered neuronal/synaptic activity, a reduced glutamatergic projection from ACC to the ventral hippocampal CA1 area is suggested to contribute to depressive-like symptoms in 3-month-old 5xFAD mice (Chen et al., 2024)

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Although compounded drugs are permitted to be prescribed under federal law, they are not FDA-approved and do not undergo safety, effectiveness, or manufacturing review

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Retatrutide alone The 24.2% weight loss observed with retatrutide at 12mg weekly is extraordinary by any standard