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Datta, H

Common Gastrointestinal Symptoms Digestive side effects manifest in approximately 50% to 60% of patients, particularly as the body acclimates to the medication or during a dose increase

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Taking moderate amounts daily tends to produce better results than occasional high intake

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In a prespecified pooled analysis, semaglutide was superior to placebo in improving heart failure-related symptoms and physical limitations, enhancing exercise tolerance, and promoting significant weight loss, underscoring its potential to address both metabolic and functional deficits in obesity-related HFpEF [49]