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It plays a vital role in the healthy functioning of many systems in the body, including the following: DNA (genetic material) synthesis Energy production (metabolism) Nerve cell health Neurological (brain) function Red blood cell (hemoglobin) formation Vitamin B12 plays a key role in the normal functioning of the brain and nervous system
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Evidence-based alternatives include optimising nutrition with iron-rich foods and complex carbohydrates, taking recommended supplements such as vitamin D (10 micrograms daily), addressing iron deficiency if confirmed by blood tests, ensuring adequate hydration, and prioritising sleep when possible
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It was first formally described in the scientific literature in 1993 by a team of researchers led by Sikiric and colleagues
Long-term use of metformin, a drug commonly prescribed for type 2 diabetes, is strongly associated with vitamin B12 deficiency and lower folic acid levels as it can block absorption, which may lead to increased homocysteine levels and risk for cardiovascular disease
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