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The key indicator of cellular health is the ratio of reduced glutathione (GSH) to oxidized glutathione (GSSG)
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The primary sources of oxidative stress in sperm include leukocyte activity, mitochondrial dysfunction, and environmental factors such as smoking and pollution
Glutathione (GSH) is a tripeptide molecule made from three amino acids: Cysteine (rate-limiting amino acid-contains sulfur) Glycine Glutamate It exists in two forms: Reduced glutathione (GSH) : Active form, the antioxidant Oxidized glutathione (GSSG) : Inactive form, created when GSH neutralizes free radicals The GSH:GSSG ratio is a critical marker of oxidative stress
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