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In late-stage trials aficamten improved exercise capacity and reduced symptoms in patients with the condition

The SURMOUNT-5 trial (Rosenstock et al., Lancet 2025) showed 24.2% mean weight loss at 48 weeks, compared to 15.7% for semaglutide 2.4 mg

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Since the beginning of the industrial revolution of the mid 1800s and technological revolution of the late 1900s there has been a dramatic change in both physical activity and food availability (5)

ACC/AHA guidelines flag levels above 2.0 mg/L as higher cardiovascular risk