Subcutaneous Pediatric Dosage Regimen The recommended subcutaneous dosage of HUMIRA for pediatric patients 5 years of age and older with moderately to severely active ulcerative colitis, based on body weight, is shown below: 2.6 Recommended Dosage in Plaque Psoriasis or Adults with Uveitis The recommended subcutaneous dosage of HUMIRA for adult patients with plaque psoriasis (Ps) or uveitis (UV) [see Indications and Usage (1.7, 1.9)] is an initial dose of 80 mg, followed by 40 mg given every other week starting one week after the initial dose
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Research in rodents indicates that apart from the activation of MMP2, the peptide might also activate fibroblasts, which produce and maintain MMP2 and other components of the extracellular matrix, such as collagen and elastin
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