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Mice exposed to chronic unpredictable mild stress (CUMS) for 6 weeks showed increased hypothalamic corticotropin-releasing hormone concentrations, elevated corticosterone levels and increased blood ammonia, which corresponded with anxiety-like behaviors, demonstrating HPA axis involvement in anxiety pathogenesis (Jia et al., 2024)
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Furthermore, owing to the single-blind design, these results should not be treated as evidence of symptomatic or disease-modifying efficacy of exenatide [17]
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