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PT-141's linear structure allows greater conformational flexibility, which paradoxically increases selectivity for MC3R and MC4R while reducing activity at MC1R (the pigmentation receptor)

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Wegovy injection showed weight loss of 15% in its key trial, versus 2% for placebo, while Zepbound showed 21% on its highest dose, compared with 3% for those on placebo

Do GLP-1s and GIPs work the same way for everyone, or can results vary from person to person