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Licensed pharmacological options such as orlistat and semaglutide (Wegovy, per NICE TA875) may be appropriate for eligible individuals

Two years after they stopped taking semaglutide, their weight and free testosterone levels remained significantly lower

And just like insulin, you can get some pretty decent results by giving GLP-1 to people with obesity and/or metabolic syndrome

Semaglutide delays stomach emptying

But it does mean monitoring is important, especially for patients who already take blood pressure medications, diuretics, heart failure medications, or medications that affect fluid balance