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When exposed to increasing gradients of the stimulus, wt animals exhibited a pulsatile activity that adapted to the magnitude of the gradient's first derivative (Fig 6A)

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Expression of CYP4F2 in human liver and kidney: assessment using targeted peptide antibodies

Additionally, the free (unbound) concentration of certain drugs can decrease during pregnancy due to a notable drop of albumin and alpha-1-acid glycoprotein concentration (Murphy et al

In a combined protocol, even slower titration makes theoretical sense to monitor for interactions