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Obstructive Sleep Apnea (OSA): By facilitating significant weight loss, GLP-1s can reduce the fat deposits around the neck and throat that cause OSA, leading to an improvement in symptoms and overall sleep quality
145 Telaglenastat, a glutaminase inhibitor, was also evaluated in combination with everolimus (TelaE) in a phase I trial of advanced/metastatic renal cell carcinoma (mRCC), and TelaE therapy was well tolerated in patients previously treated with TKIs and checkpoint inhibitors (NCT03163667)
This metabolic shift occurs without changes in total energy expenditure, suggesting improved efficiency rather than increased caloric burn
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These models include those of neonatal hippocampal lesion, expression of mutant DISC1 protein and genetic deletion of the key GSH-synthesizing enzyme
