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Journal reference: van Houtum, W., Schrombges, P., Amadid, H., et al

Further, liraglutide protects against vascular oxidative stress via attenuating eNOS (endothelial NO synthase) s-glutathionylation (a hallmark of eNOS uncoupling) and increasing NO bioavailability [15]

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Injection Site Reactions One of the most common side effects is mild discomfort at the injection site

Unlike endogenous GLP-1, which is rapidly degraded by dipeptidyl peptidase-4, GLP-1 receptor agonists are resistant to degradation and have longer half-lives, particularly for modern long-acting agents, such as liraglutide, dulaglutide, semaglutide and tirzepatide