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[8] Drmic, D., Kolenc, D., Ilic, S., & Sikiric, P

Validation of DM2 DMTs in AD prevention using blood transcriptomic data from patients with MCI To validate the impact of DM2 DMTs, including metformin, in preventing AD comorbidity in DM2, we analyzed publicly available blood transcriptomic data from patients with MCI, a well-established preclinical stage of AD

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These represent normalization of previously impaired metabolic function rather than supraphysiologic metabolic enhancement

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Conclusions: These findings suggest a new link between low peripheral serotonin, L-carnitine, and fatigue