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Avoid repeated freeze-thaw cycles, which reduce recovery of the 43-residue thymosin beta 4 chain in particular, label every aliquot with the reconstitution date, and handle throughout under sterile laboratory conditions

Translating these in vitro findings to an in vivo model, naturally aged male mice from 20-24 months old were treated with FOXO4-DRI

As an active ingredient in supplements it is not recommended, because in addition to its low efficacy a low cyanide pollution also occurs

The scientific and regulatory communities do not support its medical use