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The vasoprotective effects are most evident in models of diabetic retinopathy, where a hallmark of the disease is the breakdown of the BRB and subsequent retinal vascular leakage [61]

However, additional research shows that infliximab inhibits bone resorption markers such as C-terminal cross-linked telopeptide of type I collagen (ICTP), while increasing bone formation markers including osteocalcin and procollagen type 1 N-terminal propeptide (P1NP)

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Dionisio PA, et al

However, this pioneering approach was futile due to the relatively thick mucosal barrier and continuous flow of saliva