The first few weeks on tirzepatide are when GI side effects peak
Age and sex differences in plasma homocysteine, choline and betaine status in Seychellois children and young adults
doi: 10.3892/ijmm.2020.4498 281 BartelDP
The compounding advantage also means your dose can increase gradually at your body's pace, not on a fixed pharmaceutical schedule
Gastrointestinal effects lead: nausea, diarrhea, constipation, and vomiting, dose-dependent and clustered during escalation, mostly mild. Tirzepatide also produces a modest chronic heart-rate rise with a larger escalation-phase peak. Oral-contraceptive absorption can fall after starting and after each increase, so use backup or non-oral contraception for 4 weeks each time. What is known about concurrent metformin and tirzepatide use
B12 injections can provide energy and reduce fatigue as well as helping with low moods, 'brain fog' and healthy hair, nails and skin