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We also found that DMF induces NRF2 expression in erythroblasts and SCD mice for gene expression involved in ferroptosis and ROS stress response
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Hence, although future kinetic studies might confirm a random mechanism for the rate-limiting first part of monothiol mechanism (iii) in vitro, GSH is probably the first and the non-glutathione disulfide the second substrate under physiological conditions in vivo (Fig
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