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And on day one, it has barely moved

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When you discontinue tirzepatide, appetite gradually returns to baseline over 4 to 8 weeks as the medication clears your system

doi: 10.3389/fphar.2025.1693441 Received 27 August 2025 Revised 16 October 2025 Accepted 23 October 2025 Published 10 November 2025 Volume 16 - 2025 Edited by Guoliang Meng, Nantong University, China Reviewed by Sini Sunny, University of Alabama at Birmingham, United States Lan Wu, Shanghai University of Medicine and Health Sciences, China Maria Aslam, University of Lahore, Pakistan Updates Copyright 2025 Chen, Tang, Ren and Wu

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Generally, they are metabolized through the mercapturic acid pathway